Fig. 2From: 18F–FDG-PET/CT and diffusion-weighted MRI for monitoring a BRAF and CDK 4/6 inhibitor combination therapy in a murine model of human melanomaPET/CT VOI Selection. a and b: coronal unenhanced CT without (a) and with (b) VOIs. c and d: Fused coronal PET/CT data sets without (c) and with (d) VOIs. Note the tumor in the lateral flank (red asterisk). The liver is indicated by a white asterisk. To calculate the metabolic tumor volume, a PET/CT-guided VOI surrounding the tumor was drawn. Background was determined in a VOI in the right liver lobe and the TTL was calculated accordinglyBack to article page